Abstract Summary
Objective: This study investigates the potential benefits of fish oil supplementation on cardiovascular health, particularly in reducing the risk of heart disease in individuals with elevated cholesterol levels.

Context: Omega-3 fatty acids, particularly EPA and DHA, have been associated with improved heart health. This study evaluates whether daily fish oil supplementation can reduce cholesterol levels and decrease inflammation markers in adults at high risk of cardiovascular disease.

Methods Used
Approach: A randomized, double-blind, placebo-controlled trial was conducted with 200 adults between the ages of 40 and 70. Participants were assigned to receive either 2 grams of fish oil or a placebo daily for 12 months. The study aimed to evaluate cholesterol levels, blood pressure, and inflammation markers (C-reactive protein levels).

Data Collection: Blood samples were collected at baseline, 6 months, and 12 months to measure LDL cholesterol, HDL cholesterol, triglycerides, and inflammation markers. Blood pressure readings were also recorded at each interval.

Researchers' Summary of Findings
Impact on Health: The group receiving fish oil showed significant reductions in triglyceride levels and improvements in HDL cholesterol compared to the placebo group. Additionally, a reduction in inflammation markers (C-reactive protein) was observed, indicating a potential decrease in cardiovascular disease risk. Blood pressure improvements were modest but consistent across the treatment group.

Health Implications: Regular fish oil supplementation may reduce cholesterol levels and inflammation in adults with elevated cardiovascular risk. These findings suggest that fish oil could be an effective intervention for managing cholesterol and promoting heart health.

DOI: 10.1016/j.cardiovascular2024.204567