Vitamin C and the Common Cold: An Evidence-Based Review

Abstract Summary 

Objective: This meta-analysis evaluates the effectiveness of regular vitamin C supplementation in preventing the common cold.

Context: The common cold is one of the most widespread human illnesses. Vitamin C's role as an over-the-counter preventive therapy is popular but remains controversial.

Methods Used: A systematic literature search was conducted for randomized controlled trials on vitamin C supplementation for common cold prevention. Results were pooled using a random effects meta-analysis model.

Researchers' Summary of Findings: Regular vitamin C supplementation showed a modest but statistically significant benefit in reducing common cold incidence in the general population. Greater preventive effects were observed in subgroups including athletes and groups in extreme cold environments.

DOI: 10.3390/nu12020566