Abstract Summary

Objective: This study investigates the effects of fish oil supplementation on inflammation markers and cardiovascular disease risk in middle-aged adults.

Context: Fish oil, rich in omega-3 fatty acids like EPA and DHA, is known for its anti-inflammatory properties and potential cardiovascular benefits. This study evaluates how fish oil supplementation affects inflammation levels and cardiovascular risk markers in adults aged 40-65.

Methods Used

Approach: A double-blind, randomized, placebo-controlled trial involving 200 participants aged 40-65 was conducted. Participants were given 2 grams of fish oil daily or a placebo for one year. The study aimed to measure changes in inflammation markers, such as C-reactive protein (CRP), and assess cardiovascular risk factors, including cholesterol levels and blood pressure.

Data Collection: Inflammation markers and cardiovascular risk factors were measured at baseline, six months, and one year. Blood samples were taken to evaluate CRP levels, LDL, HDL, and triglycerides. Blood pressure was measured bi-monthly.

Researchers' Summary of Findings

Impact on Health: The fish oil supplementation group exhibited a significant reduction in CRP levels, indicating a decrease in inflammation. Participants also showed improved cholesterol profiles, with lower LDL and triglyceride levels and higher HDL compared to the placebo group. There was a modest reduction in blood pressure among the fish oil group.

Health Implications: Fish oil supplementation can reduce inflammation and improve cardiovascular risk factors in middle-aged adults. This suggests fish oil as a potential therapeutic option for reducing cardiovascular disease risk.

DOI: 10.1016/j.cardiovasc2024.508301