Abstract Summary

Objective: This study investigates the role of vitamin C supplementation in preventing the common cold.

Context: The common cold is one of the most widespread illnesses, leading to significant economic impacts due to missed work and school. Vitamin C has been frequently promoted as an over-the-counter treatment, but its effectiveness remains debated.

Methods Used

Approach: A systematic review and meta-analysis were conducted on randomized controlled trials examining vitamin C supplementation for the prevention of the common cold. Multiple databases were searched for relevant studies published between 1970-2019.

Data Sources: Analysis of existing literature and observations on vitamin C supplementation and common cold incidence.

Researchers' Summary of Findings

Health Implications: Pooled results found that regular vitamin C supplementation had a modest but statistically significant effect of reducing common cold incidence, with greater benefits seen in groups undergoing severe physical activity or cold environments. Further research is warranted to establish optimal dosing regimens.

DOI: 10.1513/AnnalsATS.202002-127FR