Abstract Summary

Objective:
To assess the impact of a ketogenic diet on fat oxidation, appetite control, and weight loss in obese women.

Context:
A ketogenic diet has been shown to promote fat oxidation and reduce hunger hormones, potentially leading to weight loss. This study aimed to investigate these effects specifically in a population of obese women.

Methods Used

Approach:
A crossover trial was employed with 40 obese women who were randomly assigned to either a ketogenic diet or a balanced diet for four weeks. After a washout period, they switched to the alternate diet for another four weeks. Fat oxidation rates, appetite levels, and weight loss were monitored throughout the study.

Data Collection:
Data on fat oxidation was collected through indirect calorimetry. Appetite was assessed via a standardized hunger questionnaire, and weight loss was measured weekly. Blood samples were taken to evaluate hormone levels related to appetite and fat metabolism.

Researchers' Summary of Findings
Women following the ketogenic diet experienced significantly higher rates of fat oxidation and reported decreased appetite compared to those on the balanced diet. Weight loss was also greater in the ketogenic group, with an average loss of 4.8 kg compared to 2.1 kg in the balanced diet group. The findings suggest that a ketogenic diet may be particularly effective for fat loss by promoting increased fat oxidation and reducing hunger.