The Bright Side of Omega-3: Fish Oil as a Beacon of Hope for Depression

Abstract

Objective: This meta-analysis examines the efficacy of fish oil supplementation as an adjunct treatment for major depressive disorder.

Context: Omega-3 fatty acids influence neurotransmitter systems implicated in depression. But past studies on their clinical benefits show inconsistent results.

Methods Used

Approach: A systematic review and meta-analysis was conducted on double-blind RCTs using fish oil to treat major depression.

Data Collection: 16 placebo-controlled trials with over 1,200 participants were included. EPA and DHA dosages ranged from 200 to 2,200 mg/day. Depression severity was assessed on standardized scales.

Researchers' Summary of Findings

Impact on Health: Fish oil supplementation significantly reduced depression symptoms compared to placebo. The benefit was greater in higher quality and higher dose trials.

Health Implications: Fish oil can serve as an effective supplemental treatment for depression, particularly at doses over 1,000 mg/day.

DOI: 10.1002/14651858.CD004692.pub3